Not much idea about all this so I do hope im in the right forum category. I've used both SNRIs and SSRIs for chronic fatigue and my ADHD. Cymbalta initially worked pretty well, not just for fatigue, but surprisingly also for ED. But, after a period of intense stress and fatigue about 3 months in, it suddenly just stopped functioning and even started making me feel a lot worse. Other SSRIs also lost their effect around the same time. The only exception has been Prozac, it remained consistently helpful and feels similar to how Cymbalta felt at first, even improving my ED. I know Prozac is a 5-HT2C antagonist, so I was wondering if that plays a role. The only issue is that it seems to raise dopamine, which actually worsens my ADHD, even though norepinephrine helps. Im worried Prozac might stop working as well. Would really appreciate any insight as to why antidepressants lose effectiveness over time and how Prozac works. Suggetsions for medications too please.
